SUMMARY
The MDR/XDR-TB Colour Test is a simple, safe, low-cost, appropriate-technology test for diagnosing TB and concurrently determining antibiotic-susceptibility testing. This test helps ensure that patients in resource-constrained settings receive the best treatment for their TB disease. The MDR/XDR-TB Colour Test was invented and developed by the IFHAD research group in Peru and has since been evaluated in multiple countries – please see the publications below.
PROTOCOL
The current MDR/XDR-TB Colour Test protocol may be downloaded from this link: https://www.dropbox.com/s/doffh2qq6xvtwhj/20140610_Colour_Test_SOP%20v9_English_CLEANED.docx?dl=0
This file includes links to previous versions of the protocol.
Further information is available from carlton.evans@ifhad.org
2007
ABSTRACTS
ABSTRACT. Herrera B, Ramos E, Gilman RH, Grandjean L, Martin L, Alvarado J, Quino W, Valencia T, Sandhu G, Montoya R, Alva J, Franco J, Haro M, Sosa R, Valera E, Valiente B, Rivero M, Carrera S, Escombe AR, Curatola A, Evans CA.
Optimisation of TB field testing: in-transit sputum decontamination & culture on colorimetric selective media for TB diagnosis & drug-susceptibility testing
Poster presentation, p.15.
In proceedings of the Medecins Sans Frontieres (MSF); Campaign for Access to Essential Medicines.
One day symposium on TB field Diagnostics ‘Dying for a test: 7 November 2007; Cape Town, South Africa.
Open access: https://msfaccess.org/sites/default/files/MSF_assets/TB/Docs/TB_event_DyingforaTest_ENG_2007.pdf
Traducción al español/Spanish language translation: updating
2007 abstracts ASTMH Philadelphia
ABSTRACT. Shell SS*, Ramos E*, Herrera B*, Gilman RH, Quino W, Alvarado J, Valencia T, Sandhu G, Rivero M, Carrera S, Montoya R, Alva J, Franco J, Haro M, Sosa R, Valera E, Valiente B, Curatola A, Escombe AR, Moore DAJ, Sheen P, Evans CA.(*Joint first authors)
Enhancing tuberculosis culture diagnosis with the colorimetric indicator STC
Poster presentation.
In Proceedings of the 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene: 4-8 November 2007; Philadelphia, PA USA.
American Journal of Tropical Medicine and Hygiene 2007;77.
Open access: PDF
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2008
ABSTRACTS
2008 abstracts IUATLD Paris
ABSTRACT. Herrera B, Ramos E, Gilman R, Grandjean L, Martin L, Alvarado J, Quino W, Sandhu G, Alva J, Sosa R, Carrera S, Coleman D, Mitchison D, Evans C.
A Simple colour test for diagnosing MDRTB & XDRTB under field conditions therapy
Oral prize scholarship presentation, CDC late-breaker session on TB.
In Proceedings of the 39th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 16-20 October 2008; Paris, France.
Open access: PDF
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ABSTRACT. Herrera B, Ramos E, Gilman R, Grandjean L, Martin L, Alvarado J, Valencia T, Quino W, Sandhu G, Alva J, Sosa R, Carrera S, Coleman D, Mitchison D, Evans CA.
Simplifying culture-based TB/MDRTB testing for peripherals labs
Invited oral presentation by Evans CA.
FIND Scientific Forum on Recent Advances in TB Diagnostics: 17 October 2008; Paris.
Open access: PDF
Alternative open access: PDF
Traducción al español/Spanish language translation: Click here
2009
ABSTRACTS
ABSTRACT. Tovar M, Valencia T, Gilman R, Caviedes L, Ramos E, Alvarado J, Quino W, Herrera B, Evans C.
Validation of the Microscopic-Observation Drug-Susceptibility (MODS) technique for drug-susceptibility testing during tuberculosis therapy
Prize oral presentation with young investigator scholarship 734, 18 November 2009.
In Proceedings of the 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH): 18-22 November 2009; Washington DC, USA.
American Journal of Tropical Medicine and Hygiene 2009;81(5 Suppl 1):212. https://doi.org/10.4269/ajtmh.2009.81.201
Open access: http://www.ajtmh.org/content/journals/10.4269/ajtmh.2009.81.201
Alternative open access: PDF
Traducción al español/Spanish language translation: updating
2010
ABSTRACTS
ABSTRACT. Tovar M, Schumacher SG, Osorio C, Ramos E, Llacza M, Herrera B, Gilman RH, Evans CA.
A simple colour test for diagnosing MDR-B and XDR-TB under field conditions
Abstract presentation PC-101296-13, 13 November 2010.
In Proceedings of the 41st World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 11-15 November 2010; Berlin, Germany.
International Journal of Tuberculosis and Lung Disease 2010;14(11 Suppl 2):S73.
Open access: PDF
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2010 abstracts IUATLD Berlin
ABSTRACT. Schumacher SG, Valencia T, Montoya R, Tovar M, Gavino A, Carrera S, Gilman RH, Evans CA.
Operational effectiveness of TB culture and drug susceptibility testing in a high-prevalence setting
Abstract presentation PC-100042-13, 13 November 2010
In Proceedings of the 41st World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 11-15 November 2010; Berlin, Germany.
International Journal of Tuberculosis and Lung Disease 2010;14(11 Suppl 2):S72-73.
Open access: PDF
Traducción al español/Spanish language translation: Click here
2011
ABSTRACTS
ABSTRACT. Tovar MA, Schumacher SG, Osorio C, Ramos E, Llacza M, Valencia T, Herrera B, Evans CA.
Comparison of TB diagnosis with the MDR-/XDR-TB colour test and MODS
Abstract presentation PC-1270-29, 29 October 2011.
In Proceedings of the 42nd World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 26-30 October 2011; Lille, France.
International Journal of Tuberculosis and Lung Disease 2011;15(11 Suppl 3):S274.
Open access: PDF
Traducción al español/Spanish language translation: updating
2012
MAJOR PUBLICATIONS
Toit K, Mitchell S, Balabanova Y, Evans CA, Kummik T, Nikolayevskyy V, Drobniewski F.
The colour test for drug susceptibility testing of Mycobacterium tuberculosis strains
International Journal of Tuberculosis and Lung Disease 2012;16(8):1113-8. doi: 10.5588/ijtld.11.0609.
Open access: https://pubmed.ncbi.nlm.nih.gov/22762424/
Alternative open access: PDF
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ABSTRACTS
ABSTRACT. Rocha C, Tilley D, Ching M, Ramos E, Tovar M, Rivera E, Cortegana L, Evans C.
Field assessment of tuberculosis culture techniques in a resource-poor jungle setting
Abstract presentation PC-767-17, 17 November 2012.
In Proceedings of the 43rd World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 13-17 November 2012; Kuala Lumpur, Malaysia.
International Journal of Tuberculosis and Lung Disease 2012;16(12 Suppl 1):S430.
Open access: PDF
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2013
ABSTRACTS
2013 abstracts IUATLD Paris
ABSTRACT. Rocha C, Tilley DH, Ching M, Ramos E, Tovar MA, Rivera E, Cortegana L, Evans C.
Comparison of time to MDR-TB diagnosis with the MDR/XDR-TB Colour Test and current algorithm in a resource-poor jungle setting in Peru
Abstract presentation PC-876-03, 3 November 2013.
In Proceedings of the 44th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 30 October-3 November 2013; Paris, France.
International Journal of Tuberculosis and Lung Disease 2013;17(12 Suppl 2):S472.
Open access: PDF
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ABSTRACT. Wendell J, Hanson Herrera B, Ramos E, Tovar M, Schumacher S, Valencia T, Coleman D, Evans C.
The MDR/XDR-TB colour test simultaneous culture and drug susceptibility results predict tuberculosis outcomes
Abstract presentation OP-242-03, 2 November 2013.
In Proceedings of the 44th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 30 October-3 November 2013; Paris, France.
International Journal of Tuberculosis and Lung Disease 2013;17(12 Suppl 2):S271-272.
Open access: PDF
Traducción al español/Spanish language translation: Click here
ABSTRACT. Ramos E, Coleman D, Osorio CE, Valencia TR, Llacza M, Tovar M, Wingfield T, Evans C.
Carbendazim reduces contamination of tuberculosis cultures in the thin layer agar MDR/XDR-tuberculosis Colour Test
Abstract presentation OP-243-02, 2 November 2013.
In Proceedings of the 44th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 30 October-3 November 2013; Paris, France.
International Journal of Tuberculosis and Lung Disease 2013;17(12 Suppl 2):S272.
Open access: PDF
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2013 abstracts IUATLD Vancouver
ABSTRACT. Ramos ES, Osorio CE, Valencia TR, Llacza MF, Tovar MA, Montoya R, Wingfield T, Evans CA.
The specificity of the MDR-/XDR-TB Colour Test for differentiating Mycobacterium tuberculosis from atypical mycobacteria
Scholarship for Ramos E, p.71.
In Proceedings of the 17th Annual Conference of the International Union Against Tuberculosis and Lung Disease North America Region and National Tuberculosis Controllers Association: 28 February -2 March 2013; Vancouver, BC, Canada.
Open access: PDF
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2014
ABSTRACTS
2014 abstracts IUATLD Barcelona
ABSTRACT. Ramos E, Sloutsky A, Osorio CE, Valencia T, Llacza M, Ching M, Tovar M, Evans C.
High-tuberculosis diagnostic yield from culturing salivary sputum samples
Abstract presentation PD-826-31, 31 October 2014.
In Proceedings of the 45th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 28 October-1 November 2014; Barcelona, Spain.
International Journal of Tuberculosis and Lung Disease 2014;18(11 Suppl 1):S285.
Open access: PDF
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ABSTRACT. Tovar MA, Valencia T, Carrera S, Ramos E, Wingfield T, Montoya R, Rivero M, Evans CA.
Undiagnosed tuberculosis cases among previously tuberculosis-affected families: results of a prevalence survey in Peru
Abstract presentation OAP-234-30, 30 October 2014.
In Proceedings of the 45th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 28 October- 1 November 2014; Barcelona, Spain.
International Journal of Tuberculosis and Lung Disease 2014;18(11 Suppl 1):S221.
Open access: PDF
Traducción al español/Spanish language translation: Click here
2015
ABSTRACTS
ABSTRACT. Tovar M, Ramos E, Valencia T, Datta S, Montoya R, Wingfield T, Valencia A, Patrocinio R, Evans CA.
Comparison of the MDR/XDR-TB Colour Test, Xpert ® MTB/RIF, and MODS assays to diagnose rifampicin-resistant TB
Poster discussion PC-1029-05, 5 December 2015.
In Proceedings of the 46th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 2-6 December 2015; Cape Town, South Africa.
International Journal of Tuberculosis and Lung Disease 2015;19(12 Suppl 2):S368.
Open access: PDF
Traducción al español/Spanish language translation: Click here
2016
ABSTRACTS
ABSTRACT. Tovar M, Wingfield T, Saunders M, Montoya R, Ramos E, Valencia T, Datta S, Evans CA.
Risk factors associated with undetected pulmonary TB in a prevalence survey, Callao, Peru
Abstract presentation OA-392-28, 28 October 2016.
In Proceedings of the 47th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 26-29 October 2016; Liverpool, UK.
International Journal of Tuberculosis and Lung Disease 2016;20(11 Suppl 1):S255.
Open access: PDF
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2017
ABSTRACTS
ABSTRACT. Datta S, Tovar M, Valencia T, Ramos E, Montoya R, Lewis J, Evans CA.
Sputum collection factors affecting diagnostic yield
Short oral presentation SOA-377-12, 12 October 2017.
In Proceedings of the 48th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 11-14 October 2017; Guadalajara, Mexico.
International Journal of Tuberculosis and Lung Disease 2017;21(11 Suppl 2): S188
Open access: PDF
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2018
MAJOR PULICATIONS
Zhang A, Jumbe E, Krysiak R, Sidiki S, V Kelley H, Chemey EK, Kamba C, Mwapasa V, Garcia JI, Norris A, Pan XJ, Evans CA, Wang S-H, Kwiek JJ, Torrelles JB.
Low-cost diagnostic test for susceptible and drug-resistant tuberculosis in rural Malawi
African Journal of Laboratory Medicine 2018;7(1):a690. doi: 10.4102/ajlm.v7i1.690.
Open access: https://www.ncbi.nlm.nih.gov/pubmed/29977794
Alternative open access: PDF
Traducción al español/Spanish language translation: updating
ABSTRACTS
2018 Abstract ECCMID Madrid
ABSTRACT. Datta S, Tovar MA, Wingfield T, Patrocinio R, Montoya R,, Valencia T, Gilman RH, Evans CA.
Monitoring tuberculosis treatment response with conventional laboratory tests during the first 14-days of therapy has no clinical value
Poster presentation P0981, 22 April 2018.
In Proceedings of the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID): 21-24 April 2018; Madrid, Spain.
Open access: https://www.escmid.org/fileadmin/eccmid/2018/media/documents/escmid-final-programme-madrid-web.pdf
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2019
MAJOR PUBLICATIONS
Mekonnen B, Mihret A, Getahun M, Hailu T, Sidiki S, V Kelley H, Scordo JM, Hunt WG, Pan X, Balada-Llasat JM, Gebreyes W, Evans CA, Aseffa A, Torrelles JB, Wang SH, Abebe T.
Evaluation of the tuberculosis culture color plate test for rapid detection of drug susceptible and drug-resistant Mycobacterium tuberculosis in a resource-limited Setting, Addis Ababa, Ethiopia
PLoS ONE 2019;14(5):e0215679. doi: 10.1371/journal.pone.0215679.
Open access: https://www.ncbi.nlm.nih.gov/pubmed/31136575/
Traducción al español/Spanish language translation: Click here
Shibabaw A, Gelaw B, Kelley H, Balada-Llasat JM, Evans CA, Wang SH, Torrelles JB, Tessema B.
Accuracy of the color plate micro-colony detection for the diagnosis of Mycobacterium tuberculosis complex in Northwest Ethiopia
Tuberculosis 2019;114:54-60. doi: 10.1016/j.tube.2018.11.007.
Open access: PDF
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ABSTRACTS
ABSTRACT. Wilson JP, Valencia T, Montoya R, Ramos ES, Avarado K, Bernaola L, Bailón N, Herrera B, Datta S, Evans CA.
Diagnostic sensitivity and time-to-detection (TTD): a direct comparison between the MDR/XDR-TB colour test and established liquid and solid culture techniques
Short oral presentation SOA-16-1164-02, 2 November 2019.
In Proceedings of the 50th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease (The Union): 30 October – 2 November 2019; Hyderabad, India.
International Journal of Tuberculosis and Lung Disease 2019;23(10 Suppl 1):S444.
Open access: PDF
Traducción al español/Spanish language translation: updating
2020
MAJOR PUBLICATIONS
Shibabaw A, Gelaw B, Kelley HV, Tesfaye E, Balada-Llasat JM, Evans CA, Torrelles JB, Wang SH, Tessema B.
MDR/XDR-TB colour test for drug susceptibility testing of Mycobacterium tuberculosis, Northwest Ethiopia
International Journal of Infectious Diseases 2020;90:213-218. doi: 10.1016/j.ijid.2019.10.041.
Open access: https://www.ncbi.nlm.nih.gov/pubmed/31689528
Alternative open access: https://www.ijidonline.com/article/S1201-9712(19)30435-7/fulltext
Alternative open access: PDF
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